Evidence map›Paper›PMID 41608385›Full record

ArticleJournal of cellular signaling2025

PAX-Interacting Protein 1 (PTIP) Promotes Apoptosis.

Ching-Jung Huang, Hyein Cho, Chuan Li, Kangsan Kim, Danyang Yu, Daechan Park, Y Jessie Zhang, Haley O Tucker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ching-Jung HuangDepartment of Biology, Arts and Sciences, New York University in Shanghai, Shanghai 200122, China.
Hyein ChoDepartment of Molecular Science and Technology, Advanced College of Bio-Convergence Engineering, Ajou University 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, South Korea.
Chuan LiMolecular Biosciences, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.
Kangsan KimMolecular Biosciences, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.
Danyang YuDepartment of Biology, Arts and Sciences, New York University in Shanghai, Shanghai 200122, China.
Daechan ParkDepartment of Molecular Science and Technology, Advanced College of Bio-Convergence Engineering, Ajou University 206 Worldcup-ro, Yeongtong-gu, Suwon 16499, South Korea.
Y Jessie ZhangMolecular Biosciences, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.
Haley O TuckerMolecular Biosciences, University of Texas at Austin, 1 University Station A5000, Austin, TX 78712, USA.

Funding

MAR MEDIATED GENETIC SWITCH FOR IGH ENHANCER CONTROLR01CA031534 · NCI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI TUCKER, HALEY O · 1985 to 2012
$2.9M
Elucidating the SCP4 pathway as a multi-catalytic signaling dependency in acute myeloid leukemiaR01CA281106 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Christopher Vakoc, Yan Jessie Zhang · 2023 to 2026
$2.9M
Deciphering the phosphorylation pattern of RNA polymerase II for eukaryotic transcriptionR35GM148356 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yan Jessie Zhang · 2023 to 2026
$2.3M
NCI NIH HHS R01 CA031534NCI NIH HHS R01 CA281106NIGMS NIH HHS R35 GM148356
6 · The paper itself

Abstract

PAX-interacting protein 1 (PTIP/PAXIP1) was discovered and initially characterized over three decades ago as a 1,056 amino acid-containing protein with six tandem BReast cancer C-Terminal (BRCT) repeats. PTIP functions broadly to catalyze histone methylation in DNA damage repair and within the hematopoietic lineage, to promote immunoglobulin variable region (variable, diversity, joining [VDJ]) and class switch recombination (CSR). In this report, we show that a fraction of PTIP is actively transported from the nucleus to mitochondria resulting in their aggregation, release of cytochrome c into the cytoplasm and cellular apoptosis. Deletion of an N-terminal glutamine-rich region (QR), mutation of a conserved threonine within BRCT3 and truncation of the C-terminal BRCT5 domain each significantly reduced apoptosis as well as its previously documented G

Indexed as

Breast cancer C-TerminalClass switch recombinationDNAImmunoglobulin

Identifiers

PMID41608385
PMCPMC12842040

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.