Evidence map›Paper›PMID 41608325›Full record

ReviewFrontiers in pediatrics2025

The interplay between childhood obesity and vitamin D deficiency: mechanisms and implications.

Xiao Zhou, Yuhe Chen, Jianxin Xu, Xiaobing Li, Yanmei Wu, Lidan Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiao ZhouDepartment of Pediatrics, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China.
Yuhe ChenDepartment of Pediatrics, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China.
Jianxin XuDepartment of Pediatrics, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China.
Xiaobing LiDepartment of Pediatrics, Jinhua Maternal and Child Health Care Hospital, Jinhua, Zhejiang, China.
Yanmei WuDepartment of Pediatrics, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Lidan XuDepartment of Pediatrics, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood obesity and vitamin D deficiency (VDD) are intertwined global health threats that amplify each other beyond their individual skeletal or metabolic consequences. This review synthesises a decade of clinical, translational and Mendelian-randomisation evidence to show that obesity drives VDD through volume dilution, adipose-tissue sequestration and metabolic associated steatotic liver disease (MASLD)-related hydroxylase dysfunction, while VDD in turn aggravates adipogenesis, leptin resistance and chronic low-grade inflammation, locking children into a self-perpetuating cycle. Meta-analysis of 12 randomised trials (

Indexed as

childhood obesityobesity managementvitamin D deficiencyvitamin D signalingvitamin D supplementation

Identifiers

PMID41608325
PMCPMC12835314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.