Evidence map›Paper›PMID 41608316›Full record

ArticleMediators of inflammation2026

FT3 Levels and Systemic Inflammation: Evidence From a Population-Based NHANES Analysis.

Liu Yang, Han-Yu Wang, Meng-Fei Fu, Yu-Han Zhang, Xiao Chen, Zi-Xuan Wang, Hui Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liu YangDepartment of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, hust.edu.cn.ORCID https://orcid.org/0009-0005-5237-0235
Han-Yu WangDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, hust.edu.cn.ORCID https://orcid.org/0000-0002-0771-3244
Meng-Fei FuDepartment of Endocrinology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, xzmc.edu.cn.
Yu-Han ZhangDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, hust.edu.cn.
Xiao ChenDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, hust.edu.cn.
Zi-Xuan WangDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, hust.edu.cn.
Hui SunDepartment of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, hust.edu.cn.ORCID https://orcid.org/0000-0002-7684-4715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Previous studies suggest a complex interaction between 3,3',5-triiodo-L-thyronine (T3) and inflammation, but this relationship remains unclear. This study investigates the association between free triiodothyronine (FT3) levels and inflammatory markers in the US population using National Health and Nutrition Examination Survey (NHANES) data. Methods: This study analyzed NHANES data from three cycles between 2007 and 2012, using Spearman correlation tests and multivariate linear regression. Subgroup analyses and interaction tests were conducted based on age, gender, race, body mass index (BMI), thyroid-stimulating hormone, and free thyroxine (T4) to determine the correlations between FT3 and seven systemic inflammatory markers: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-white blood cell ratio (PWR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Results: A total of 2306 participants were included in this study. Univariate correlation analysis showed that CRP, NLR, MLR, and PLR were significantly negatively correlated with FT3 levels (all Conclusion: In the general population, FT3 levels exhibit inverse associations with systemic inflammatory markers.

Indexed as

InflammationTriiodothyronineAdultAgedBiomarkersBody Mass IndexC-Reactive ProteinFemaleHumansLymphocytesMaleMiddle AgedNeutrophilsNutrition SurveysThyrotropinThyroxineBiomarkersC-Reactive ProteinThyrotropinThyroxineTriiodothyronineFT3inflammatory markersNHANESpopulation-based cross-sectional studythyroid function

Identifiers

PMID41608316
PMCPMC12835195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.