ArticleKidney medicine2026
The Incidence and Risk Factors of Gout in Non-dialysis Chronic Kidney Disease Patients With Asymptomatic Hyperuricemia.
Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Nucleotide Metabolism in Health and Disease.MedComm · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale & Objective: Gout frequently complicates chronic kidney disease (CKD), yet the incidence and specific risk factors for gout in patients with CKD and asymptomatic hyperuricemia remain unclear. We aimed to determine gout incidence and risk factors in nondialysis patients with CKD and asymptomatic hyperuricemia. Study Design: Retrospective cohort study. Setting & Participants: Analysis of 771 ambulatory nondialysis patients with CKD (stages 3-5) with asymptomatic hyperuricemia (serum urate level, ≥7.0 mg/dL), without prior gout, followed from 2010 to 2023 at a single center. Predictors: Multiple clinical and laboratory factors were evaluated, including demographics, comorbidities, medications, and biochemical markers. Outcomes: Incident gout diagnosis confirmed by rheumatology specialists. Analytical Approach: Cox proportional hazards models and receiver operating characteristic curve analyses. A composite weighted index was derived from regression-based predictors. Results: Over a median follow-up of 47 months, gout developed in 140 (18.2%) patients (incidence rate, 41.9 cases per 1,000 person-years). Independent predictors of gout included younger age (per year; hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.96-0.99), higher serum urate (per 1 mg/dL; HR, 1.29; 95% CI, 1.14-1.46), lower serum creatinine levels (per 1 mg/dL; HR, 0.81; 95% CI, 0.65-0.99), and diuretic use (HR, 1.86; 95% CI, 1.00-3.45). Higher composite weighted index (per 1 unit; HR, 2.19; 95% CI, 1.70-2.83) was associated with increased gout risk. Limitations: Single-center, retrospective study design limits generalizability and causal inference. Conclusions: Incident gout is common among patients with CKD and asymptomatic hyperuricemia. Younger age, elevated serum urate levels, lower creatinine levels, and diuretic use significantly predict gout onset. Identifying high-risk patients using these predictors could guide preventive therapeutic decisions.
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