ArticleJuntendo medical journal2025
Exploring the Role of the Extracellular Matrix in Disease and Aging.
Article in Juntendo medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
1 author.
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Abstract
Throughout my research career, I have focused on understanding the extracellular matrix (ECM) and its roles in disease pathogenesis and the aging process. My initial interest in muscular dystrophies gradually expanded to include various organs and systems, including the kidneys, brain, cartilage, skin, and eyes. During my tenure at the National Institutes of Health (NIH), I made substantial contributions to generating and analyzing conditional knockout mouse models for key ECM molecules, including laminin α1 and perlecan. These studies elucidated the roles of ECM components in hereditary diseases, embryonic development, and the functionality of the neuromuscular junction. Upon returning to Japan, I transitioned this foundational expertise into translational research across multiple fields, benefiting from a collaborative environment that bridges basic and clinical sciences. My recent work examines the impact of glycosylation on ECM remodeling. Reflecting on this scientific journey, I emphasize the importance of ECM as a structural component and as a dynamic regulator of cellular behavior. As I retire from active academic life, I aspire to support the next generation of scientists in exploring the extracellular space, an area rich with potential therapeutic opportunities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.