Evidence map›Paper›PMID 41608203›Full record

ArticleMaternal-fetal medicine (Wolters Kluwer Health, Inc.)2025

Intergenerational Associations of Hypertensive Disorders of Pregnancy With Offspring Metabolomics: A Systematic Review.

Jinrui Xiong, Ling-Jun Li, Yongping Zhang, Zhihong Zhang, Yue Yang, Huan Hu, Jinhong Liu, Zimeng Chen, Peng Huang, Mengjiao Liu

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In one paragraph

Article in Maternal-fetal medicine (Wolters Kluwer Health, Inc.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinrui XiongSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.
Ling-Jun LiDepartment of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Yongping ZhangSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.
Zhihong ZhangSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.
Yue YangSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.
Huan HuSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.
Jinhong LiuSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.
Zimeng ChenSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.
Peng HuangSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.
Mengjiao LiuSchool of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To examine the impact of hypertensive disorders of pregnancy (HDP) on offspring metabolomics. Methods: We searched five databases: PubMed, Ovid Embase, MEDLINE, Web of Science, and China National Knowledge Infrastructure, and included studies that reported metabolomics among human offspring born to HDP-complicated pregnancies. Results: Database search yielded 4054 articles, and after full-text screening, ten observational studies met inclusion criteria. Half of the studies had a sample size of less than 100 and were all observational studies in preeclampsia (PE) and gestational hypertension.Neonates were the most focused group in all included studies. Offspring born to HDP-complicated pregnancies exhibited statistically significant variations in blood metabolomics compared to their counterparts, characterized by amino acids, lipids, carnitine, and others (e.g., 1α,25-(OH) Conclusion: The existing evidence suggests an intergenerational effect of HDP on offspring metabolomics. Long-term follow-up studies are needed to advance the health effects of related adverse health outcomes and inform the prevention of offspring's health. Registration: PROSPERO; CRD42023453078.

Indexed as

Gestational hypertensionHyptertensive disorders of pregnancyIntergenerational associationsMetabolomicsPreeclampsia

Identifiers

PMID41608203
PMCPMC12846856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.