ArticleJournal of the Endocrine Society2026
PFAS Alter Thyroid Histology and Cellular Signaling
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Per- and Polyfluoroalkyl Substances and Papillary Thyroid Carcinoma: An Integrative Study of Bioinformatics, Epidemiological Associations, and In Vitro Responses.International journal of molecular sciences · 2026Article
- PFAS Alter Thyroid Histology and Cellular SignalingJournal of the Endocrine Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are toxicants of emerging concern due to their abundance in the environment and potential adverse health effects. PFAS are used in waterproof clothing, makeup, carpets, upholstery, cookware, and fast-food containers. Due to their universal use, they are found globally in the water supply. In fact, these organic pollutants have been found in the blood of 98% of Americans and have been linked to disruption in thyroid hormone biosynthesis and availability. Moreover, several studies have shown that cancer patients may have an increase in PFAS levels and that PFAS exposure increases thyroid cancer risk. Demonstration of concrete PFAS-mediated alterations in thyroid histology and function could have far-reaching implications. To understand the effects of PFAS on thyroid histology, we used a PFAS feeding model with a combination of 3 PFAS compounds (PFOS, PFOA, and GenX) vs control. Mice receiving PFAS treatment showed altered thyroid architecture and cell structure following PFAS exposure. RNA-sequencing data revealed several alterations in gene expression and multiple signaling pathways were dysregulated. Understanding the role of PFAS-mediated toxicity in the thyroid is critically important for the prevention of thyroid disease in the general population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.