Evidence map›Paper›PMID 41608182›Full record

ArticleFrontiers in psychology2025

Abnormal spontaneous regional white-matter brain activity in patients with obsessive-compulsive disorder.

Yanan Shen, Tianyue Wang, Yongyi Ye, Shumei Li, Peiru Wu, Changhe Fan, Guihua Jiang

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Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yanan Shen *Department of Radiology, Taizhou Hospital of Zhejiang Province, Taizhou, China.
Tianyue Wang *The Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Yongyi Ye *The Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Shumei LiThe Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Peiru WuDepartment of Radiology, Dongguan Songshan Lake Central Hospital, Dongguan, China.
Changhe FanDepartment of Psychiatry, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Guihua JiangThe Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Previous studies on white matter (WM) in patients with obsessive-compulsive disorder (OCD) have focused primarily on its structural aspects. This study aimed to investigate any abnormal spontaneous WM neural activity in patients with OCD. Methods: The study was based on resting-state functional magnetic resonance imaging (fMRI) data from 27 patients with OCD and 24 matched healthy controls (HC). Regional homogeneity (ReHo) and the amplitude of low-frequency fluctuation (ALFF) were used to explore spontaneous neural activity changes in the subjects' WM regions. A two-sample Student's Results: The ReHo in the left posterior limb of the internal capsule (LPLIC) and right superior corona radiata (RSCR) of the OCD group was significantly higher than those in the HCs (pTFCE-FWE < 0.001). The ALFFs in the right superior longitudinal fasciculus (RSLF) and right cerebral peduncle (RCP) of the OCD group, by contrast, were significantly lower than those in the HCs (pTFCE-FWE < 0.05). There was no correlation between the clinical symptoms of patients with OCD and their abnormal amplitude of low-frequency fluctuation (ALFF) and ReHo values. Discussion: Abnormal spontaneous WM activity was observed in several brain regions in patients with OCD. This activity may help explain the cognitive inflexibility often observed in this patient group.

Indexed as

functional magnetic resonance imagingNeurologyobsessive-compulsive disorderPsychiatrywhite matter

Identifiers

PMID41608182
PMCPMC12834757

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