Evidence map›Paper›PMID 41608130›Full record

ArticleMedical hypothesis, discovery & innovation ophthalmology journal2025

Evaluating the predictive value of optical coherence tomography angiography metrics and central corneal thickness among glaucoma suspect patients: a comparative cross-sectional study.

Fathy Mohamed Abo Elftouh Elsalhy, Sarah Abbas Alshamarti, Saif Abbas Alshamarti, Abdelrahman Ahmed Ali Khattab, Mahmoud Mohammed Ahmed Ali Khalil, Mahmoud Fawzy Zaky Morsy, Ahmad Mohammad Salah Eldeen Abdul Hay, Ezzat Nabil Abbas Ibrahim, Ahmed Mohammed Madinah Alkady, Mahmoud Ahmed Shafeek and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical hypothesis, discovery & innovation ophthalmology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fathy Mohamed Abo Elftouh ElsalhyFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Sarah Abbas AlshamartiFaculty of Medicine, University of Al-Qadisiyah, Iraq.
Saif Abbas AlshamartiFaculty of Medicine, University of Al-Qadisiyah, Iraq.
Abdelrahman Ahmed Ali KhattabFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mahmoud Mohammed Ahmed Ali KhalilFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mahmoud Fawzy Zaky MorsyFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmad Mohammad Salah Eldeen Abdul HayFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ezzat Nabil Abbas IbrahimFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed Mohammed Madinah AlkadyFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mahmoud Ahmed ShafeekFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Bassem Ismail Khalil GomaaFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed Sayed Taha AbouzeidFaculty of Medicine, Beni Suef university, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glaucoma suspects (GS) exhibit risk factors such as elevated intraocular pressure (IOP), suspicious optic disc or retinal nerve fiber layer (RNFL) findings, or a positive family history, yet their risk of progression varies widely. Optical coherence tomography angiography (OCTA) and central corneal thickness (CCT) have emerged as important markers for detecting early structural and microvascular changes in GS patients. We aimed to estimate the predictive value of OCTA-derived metrics and CCT, and to assess their correlations in GS individuals. Methods: This comparative cross-sectional study included eyes from GS patients and eyes from age- and sex-matched healthy individuals as a comparison group. All participants underwent a detailed medical history and comprehensive ophthalmologic examination. Investigations included visual field perimetry; optical coherence tomography (OCT) to assess structural optic nerve head parameters, RNFL thickness, and ganglion cell layer (GCL) thickness; OCTA to measure papillary vascular density (PVD) and radial peripapillary capillary density (RPC); and non-contact specular microscopy to determine CCT. Results: The GS group had a mean age of 36.9 years, with 52.4% male (n = 11). GS eyes showed significantly larger CDR values, reduced rim area, thinner RNFL and GCL, and lower CCT compared with healthy eyes (all Conclusions: Patients with GS revealed significantly lower structural parameters and vascular metrics compared with the healthy group, and only thin CCT remained an independent predictor of GS status. Both CCT and mean RPC demonstrated good diagnostic performance for identifying GS eyes.

Indexed as

area under curvescorneal thickness measurementglaucomasintraocular pressuresoptical coherence tomographyoptic nervesperipapillary retinal nerve fiber layer thicknessradial peripapillary capillary vessel densityspecificity and sensitivity

Identifiers

PMID41608130
PMCPMC12840569

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.