Evidence map›Paper›PMID 41608123›Full record

ArticleJournal of human immunity2026

Recurrent severe viral infection in a child with inherited complete TBK1 deficiency.

Sara Sebnem Kilic, Shuxiang Zhao, Zhiyong Liu, Yasin Karali, Koray Yalcin, Aaron Bodansky, Debanjana Chakravarty, Michael Wilson, Jean-Laurent Casanova, Shen-Ying Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. AFrontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara Sebnem Kilic *Department of Pediatric Immunology-Rheumatology, Bursa Uludag University, Medical Faculty, Bursa, Turkey.ORCID https://orcid.org/0000-0001-8571-2581
Shuxiang Zhao *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID https://orcid.org/0000-0001-9185-6813
Zhiyong LiuSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID https://orcid.org/0000-0001-6473-348X
Yasin KaraliDepartment of Pediatric Immunology-Rheumatology, Bursa Uludag University, Medical Faculty, Bursa, Turkey.ORCID https://orcid.org/0000-0002-1245-4232
Koray YalcinDepartment of Pediatric Hematopoietic Stem Cell Transplantation Unit, Bahcesehir University, Medical Faculty, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-3454-9870
Aaron BodanskyDivision of Critical Care, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0001-8943-8233
Debanjana ChakravartyWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-4607-9143
Michael WilsonWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-8705-5084
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID https://orcid.org/0000-0002-7782-4169
Shen-Ying ZhangSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID https://orcid.org/0000-0002-9449-3672

Funding

Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19R01AI088364 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$8.7M
NCATS NIH HHS UL1 TR001866NIAID NIH HHS R01 AI088364
6 · The paper itself

Abstract

TANK-binding kinase 1 (TBK1) acts at the crossroads of various host immune pathways. Autosomal dominant (AD) and recessive (AR) TBK1 deficiencies have been reported in human patients with herpes simplex encephalitis and SARS-CoV-2 pneumonia (AD deficiency) or systemic inflammation (AR deficiency). We describe here a Turkish boy, born to consanguineous parents and homozygous for a loss-of-function mutation of

Identifiers

PMID41608123
PMCPMC12829739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.