Evidence map›Paper›PMID 41608086›Full record

ReviewCurrent oral health reports2026

Advances in 3D Printed Scaffolds for Periodontal Regeneration.

Arwa Daghrery, Igor Paulino Mendes Soares, Alexandre H Dos Reis-Prado, Isaac J de Souza Araújo, Renan Dal-Fabbro, Marco C Bottino

Abstract readReview
In one paragraph

Review in Current oral health reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arwa DaghreryDepartment of Restorative Dental Sciences, School of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia.
Igor Paulino Mendes SoaresDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Alexandre H Dos Reis-PradoDepartment of Restorative Dentistry, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Isaac J de Souza AraújoCollege of Dentistry, University of Saskatchewan, Saskatoon, SK Canada.
Renan Dal-FabbroDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, 1011 N. University (Room 2303), Ann Arbor, MI MI - 48109 USA.
Marco C BottinoDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, 1011 N. University (Room 2303), Ann Arbor, MI MI - 48109 USA.

Funding

Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication ApproachR01DE031476 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Marco C Bottino · 2022 to 2026
$2.6M
NIDCR NIH HHS R01 DE031476
6 · The paper itself

Abstract

Purpose of Review: To compile recent advances in scaffold-guided periodontal regeneration (SGPR) enabled by 3D printing, focusing on innovations in materials, multiphasic/anisotropic design, image-guided personalization, and the spatiotemporal delivery of therapeutic cues. Recent Findings: Composite scaffold systems, extracellular matrix (ECM)-mimetic hydrogels, and ion-releasing ceramics (e.g., Mg/Sr/Ca-phosphates, bioactive glass, among others) enhance osteogenesis, periodontal ligament (PDL) formation, and angiogenesis. Melt electrowriting, extrusion, and inkjet printing enable the creation of patient-specific, multiphasic and anisotropic scaffolds that mimic cementum-PDL-bone interfaces. Controlled release of ions, growth factors, genes, and antimicrobials modulate immunity and microenvironments. Emerging directions include in situ and 4D bioprinting, immuno-instructive and prevascularized constructs, and CAD models derived from clinical imaging, which are essential for manufacturing personalized scaffolds and grafts. Summary: 3D printing is advancing SGPR toward functional, personalized therapies; however, its translation depends on reliable vascularization, immune modulation, long-term mechanics, scalable manufacturing, and clear regulatory and safety pathways. Standardized workflows, hybrid/4D printing, machine-learning-guided design, and rigorous clinical studies are essential to accelerate clinical adoption.

Indexed as

3D printingBiomaterialsBioprintingPeriodontal regenerationPeriodontitisTissue engineering

Identifiers

PMID41608086
PMCPMC12835055

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.