Evidence map›Paper›PMID 41608054›Full record

ArticleJournal of human immunity2026

Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis.

Kevin Groen, Chau Tran, Roger Kuratli, Marie E Egan, Johannes Trück, Emanuela M Bruscia, Marc Emmenegger, Benjamin G Hale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kevin GroenInstitute of Medical Virology, University of Zurich, Zürich, Switzerland.ORCID https://orcid.org/0000-0001-6352-1346
Chau TranInstitute of Medical Virology, University of Zurich, Zürich, Switzerland.ORCID https://orcid.org/0009-0008-1993-6745
Roger KuratliInstitute of Medical Virology, University of Zurich, Zürich, Switzerland.ORCID https://orcid.org/0009-0004-2917-575X
Marie E EganDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-0567-6048
Johannes TrückDivisions of Allergy and Immunology, and the Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-0418-7381
Emanuela M BrusciaDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-2149-4057
Marc EmmeneggerDivision of Medical Immunology, Department of Laboratory Medicine, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-6073-8811
Benjamin G HaleInstitute of Medical Virology, University of Zurich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-3891-9480

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Groen et al. identify neutralizing interferon-λ2/3 autoantibodies in 11.8% of individuals with cystic fibrosis, a greater than 10-fold higher prevalence than in control individuals. Autoantibody-containing plasmas enhanced respiratory virus replication in vitro, and associated with allergic rhinitis in patients, suggesting that interferon-λ2/3 autoantibodies have the potential to impact mucosal pathology.

Identifiers

PMID41608054
PMCPMC12846703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.