Evidence map›Paper›PMID 41608051›Full record

ArticleJournal of human immunity2026

Markers of immune dysregulation in pediatric patients with severe bronchiolitis.

Katherine Hickey, Conor Gruber, Sofija Buta-Panov, Jo Hsuan Lee, Guillaume Stoffels, Sandeep Gangadharan, Alfin Vicencio, Dusan Bogunovic

Abstract read
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katherine HickeyDepartment of Pediatric Critical Care, Mount Sinai Kravis Children's Hospital, New York, NY, USA.ORCID https://orcid.org/0009-0008-7581-454X
Conor GruberDepartment of Pediatrics, Mount Sinai Kravis Children's Hospital, New York, NY, USA.ORCID https://orcid.org/0000-0002-9102-8134
Sofija Buta-PanovDepartment of Pediatrics, Center for Genetic Errors of Immunity, Columbia University Irving Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0001-7662-3851
Jo Hsuan LeeDepartment of Population Health Science and Policy, Mount Sinai Medical Center, New York, NY, USA.ORCID https://orcid.org/0009-0000-8855-876X
Guillaume StoffelsDepartment of Population Health Science and Policy, Mount Sinai Medical Center, New York, NY, USA.ORCID https://orcid.org/0009-0002-1565-5539
Sandeep GangadharanDepartment of Pediatric Critical Care, Mount Sinai Kravis Children's Hospital, New York, NY, USA.ORCID https://orcid.org/0000-0001-6751-7475
Alfin VicencioDepartment of Pediatric Pulmonology, Mount Sinai Kravis Children's Hospital, New York, NY, USA.ORCID https://orcid.org/0009-0009-0074-795X
Dusan BogunovicDepartment of Pediatrics, Center for Genetic Errors of Immunity, Columbia University Irving Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0002-9277-3232

Funding

Human ISG15 and USP18 Deficiencies Underlying Type I InterferonopathiesR01AI127372 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Dusan Bogunovic · 2017 to 2026
$4.7M
New York Regional Inborn Errors of Immunity Resource Initiative League (NY-ROYAL)R24AI167802 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dusan Bogunovic, Joshua D. Milner · 2023 to 2026
$3.3M
Immunologic and Predictive Features of MIS-CR01HD108467 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Dusan Bogunovic · 2022 to 2026
$2.7M
Inborn Errors of Immunity Leading to Autoinflammatory SyndromesR01AI148963 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOGUNOVIC, DUSAN · 2020 to 2024
$2.5M
NIAID NIH HHS R01 AI127372NIAID NIH HHS R01 AI148963NIAID NIH HHS R24 AI167802NICHD NIH HHS R01 HD108467
6 · The paper itself

Abstract

Children with bronchiolitis exhibit a unique immunophenotype. We identify a significant difference in plasmacytoid dendritic cells and eosinophils in hospitalized patients as compared to controls, as well as cytokines involved in airway inflammation that are significantly different in hospitalized patients as compared to controls.

Identifiers

PMID41608051
PMCPMC12829752

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.