ArticleBlood vessels, thrombosis & hemostasis2026
A novel transdermal curcumin gel shows potential in improving cardiac bioenergetic functions in Berkeley sickle cell mice.
Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Liposomes, Niosomes, Ethosomes, and Transethosomes for Curcumin and Chlorogenic Acid Delivery: Formulation Design and Dermal Performance.Antioxidants (Basel, Switzerland) · 2026Review
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8 authors.
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Abstract
Numerous studies have identified mitochondria as critical players in the pathophysiology of sickle cell disease (SCD). Here, we investigated the bioenergetic impairment in cardiac mitochondria as well as the putative benefits of a transdermal (TD) curcumin (VAS-101) treatment in a Berkeley SCD (BERK-SS) mouse model. Low oxygen consumption rate observed in cardiac mitochondria was indicative of impaired electron transport chain (ETC) activities in these animals. Furthermore, there was a loss of enzymatic activity primarily in complex I (reduced NAD dehydrogenase) and to a lesser degree in complex V (ATP synthase) observed in BERK-SS cardiac mitochondrial fractions. Proteomic analysis of cardiac mitochondria revealed changes in the relative abundance of proteins related to ETC complexes, especially in multiple subunits of complex I and complex V. Changes were also seen in proteins involved in several other pathways (eg, β-oxidation, glycolysis, mitochondrial protein transport, cytoskeleton, Ca
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