Evidence map›Paper›PMID 41608026›Full record

ArticleFrontiers in pharmacology2025

Antiviral activity of

Sara Alnhhas, Thamer Bouback, Abdulaziz Albeshri, Tasneem Alsahafi, Faisal Al-Sarraj, Faten A Al-Sulaimany, Mohamed Ali, Yassmin Moatasim, Omnia Kutkat, Mohamed Gaballah and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sara AlnhhasDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Thamer BoubackDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Abdulaziz AlbeshriDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Tasneem AlsahafiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Faisal Al-SarrajDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Faten A Al-SulaimanyDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Mohamed AliCenter of ScientiFIc Excellence for Influenza Viruses, Environmental Research Division, National Research Centre (NRC), Cairo, Egypt.
Yassmin MoatasimCenter of ScientiFIc Excellence for Influenza Viruses, Environmental Research Division, National Research Centre (NRC), Cairo, Egypt.
Omnia KutkatCenter of ScientiFIc Excellence for Influenza Viruses, Environmental Research Division, National Research Centre (NRC), Cairo, Egypt.
Mohamed GaballahCenter of ScientiFIc Excellence for Influenza Viruses, Environmental Research Division, National Research Centre (NRC), Cairo, Egypt.
Raied BadierahMedical Laboratory, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia.
Eman O TaibahVirology Laboratory, Lab Specialist, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Yaaser Q AlmulaikyThe Applied College, University of Jeddah, Jeddah, Saudi Arabia.
Fawaz Al-ZughaibiMicrobiology Department, Pathology and Laboratory Medicine, Prince Mohammed Bin Abdulaziz Hospital tal PMBAH, Medina, Saudi Arabia.
Mohammed MufrrihDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Saleh M Al-MaaqarDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Suzan M FathuldeenLaboratory Department, University Medical Services Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human adenoviruses (HAdVs) cause a wide range of clinical diseases, yet effective antiviral therapies remain limited. Natural products, particularly medicinal plants, offer potential sources of antiviral agents. Purpose: This study aimed to evaluate the antiviral potential of Methods: Rhizome extracts were tested on Vero cells to assess cytotoxicity and antiviral activity. GC-MS identified bioactive metabolites, which were screened against adenoviral DNA polymerase using molecular docking. Results: Docking predicted strong interactions of selected metabolites with the viral polymerase, guiding selection for Conclusion:

Indexed as

antiviral pharmacological effectsdrug-likenessGC–MSHellenia speciosa (syn. Costus speciosus)human adenovirusesmetabolitesmolecular docking

Identifiers

PMID41608026
PMCPMC12835339

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.