ArticleFrontiers in public health2025
Association between night shift work and risk of osteoporosis and osteoporosis-related pathological fracture.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The Circadian-Melatonin Axis in Bone Remodeling: Receptor-Dependent Signaling, Receptor-Independent Actions, and Translational Constraints.Biomolecules · 2026Review
- BMAL1 Proteostasis, Circadian Dysfunction, and Ferroptotic Vulnerability in Osteoporosis: Current Evidence and Experimental Priorities.Calcified tissue international · 2026Review
- Nutritional adaptation to circadian misalignment: implications for musculoskeletal health in modern lifestyles.Frontiers in nutrition · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Night shift work may increase the risk of various diseases, this study aims to explore the associations of both past and current night shift rotations with osteoporosis and its related fracture risks, and to evaluate the role of potential mediators further in the UK biobank. Methods: We investigated 276,774 UK Biobank participants with current paid employment or self-employed work, alongside 75,120 individuals with lifetime occupational history information. The multivariable-adjusted logistic regression and Cox proportional hazard models were utilized to analyze the potential links between night shift work and the incidence of OP. Moreover, stratified analyses and interaction tests were applied to explore potential modifications. Results: A total of 276,774 participants aged 40 to 69 years (mean ± SD: 52.7 ± 7.1); among them, 143,081 women (51.7%); 260,994 White participants (94.3%) were included, and a total of 5,906 OP events were documented. Relative to "day workers," all subgroups engaged in night shifts displayed a notable increase in OP prevalence ( Conclusion: This study demonstrated that both current and lifetime night shifts was significant associated with the greater risk of OP and its related pathological fracture. Additionally, these associations were not modified by genetic susceptibility. The potential of reducing night shift work as a strategy for preventing osteoporosis requires further investigation.
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