ArticleFrontiers in public health2025
Accelerometer-based physical activity, air pollution and risk of dementia subtypes: a prospective study using UK biobank.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The protective effect of physical activity on dementia risk is well established, yet the magnitude of effect remains highly inconsistent, possibly due to various approaches to physical activity measurement and potential moderating effects of environmental factors such as air pollution. Objective: To evaluate the independent and interaction effects of air pollution and accelerometer-based physical activity on incident risks of dementia subtypes. Methods: This study included 96,661 participants from the UK Biobank study with accelerometer-derived physical activity measures. Dementia diagnosis was algorithmically defined based on self-reports, primary care, hospital, and mortality records. We assessed five air pollutants, including particulate matters (PM Results: A one-IQR (10.13 milli-gravity) higher level of physical activity was significantly associated with a 30% lower risk of AD (HR = 0.7, 95% CI: 0.57-0.86, Significance: This study provides new evidence on the independent and interactive effects of objectively measured physical activity and air pollution on the risks of dementia subtypes, thereby improving the biological specificity of these associations.
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