Evidence map›Paper›PMID 41607856›Full record

ReviewMaterials today. Bio2026

Emerging roles of microfluidics in oral cancer research and clinical translation.

Zi-Zhan Li, Li-Ya Wei, Lei-Ming Cao, Guang-Rui Wang, Han-Yue Luo, Kan Zhou, Xing-Zhong Zhao, Bing Liu, Ming-Xue Zheng, Chun Xu and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zi-Zhan LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Department of Oral & Maxillofacial, Head Neck Oncology, Wuhan University, Wuhan, Hubei, 430079, China.
Li-Ya WeiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Department of Oral & Maxillofacial, Head Neck Oncology, Wuhan University, Wuhan, Hubei, 430079, China.
Lei-Ming CaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Department of Oral & Maxillofacial, Head Neck Oncology, Wuhan University, Wuhan, Hubei, 430079, China.
Guang-Rui WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Department of Oral & Maxillofacial, Head Neck Oncology, Wuhan University, Wuhan, Hubei, 430079, China.
Han-Yue LuoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Department of Oral & Maxillofacial, Head Neck Oncology, Wuhan University, Wuhan, Hubei, 430079, China.
Kan ZhouState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Department of Oral & Maxillofacial, Head Neck Oncology, Wuhan University, Wuhan, Hubei, 430079, China.
Xing-Zhong ZhaoSchool of Physics and Technology, Wuhan University, Wuhan, China.
Bing LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Department of Oral & Maxillofacial, Head Neck Oncology, Wuhan University, Wuhan, Hubei, 430079, China.
Ming-Xue ZhengDepartment of Central Laboratory, Jinan Stomatological Hospital, Jinan Key Laboratory of Oral Diseases and Tissue Regeneration & Shandong Provincial Key Medical and Health Laboratory of Oral Diseases and Tissue Regeneration, China.
Chun XuSydney Dental School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia.
Bo CaiHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan, China.
Lin-Lin BuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Department of Oral & Maxillofacial, Head Neck Oncology, Wuhan University, Wuhan, Hubei, 430079, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral cancer remains a global health burden, with limited improvements in long-term survival despite advances in multimodal therapy. Advances in early diagnosis and treatment strategies for oral cancer patients will significantly improve survival outcomes. Microfluidic technology, with its capacity for precise fluid manipulation, high-throughput analysis, and experimental miniaturization, has emerged as a powerful tool to accelerate innovations in cancer research and has become a pivotal pathway in oral cancer investigation and clinical translation. This review systematically examines the expanding roles of microfluidics in oral cancer research, with a particular focus on microfluidics-based liquid biopsy for early detection and prognosis, and microfluidics-enabled therapeutic strategies for treatment development and optimization. By bridging basic research with clinical application, microfluidics holds the potential to revolutionize early diagnosis, precision therapeutics, and functional outcome-oriented management in oral cancer, ultimately improving patient survival and quality of life.

Indexed as

Lab on a chipLiquid biopsyMicrofluidicsOral cancerSensor

Identifiers

PMID41607856
PMCPMC12834935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.