ArticleFrontiers in neurology2025
Elevated interleukin-12B is associated with increased seizure susceptibility: insights from two-sample Mendelian randomization and
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Objective: To evaluate the causality between interleukins (ILs) and epilepsy using Mendelian randomization (MR) analysis. Furthermore, Methods: All summary datasets for MR analysis were sourced from publicly available genome-wide association studies. MR analysis was utilized to assess the causal relationship between ILs and generalized epilepsy (GE). Comprehensive sensitivity analyses were carried out to verify the robustness of the findings. Additionally, seizure threshold, seizure score, and video electroencephalography recordings were conducted to evaluate the effect of IL-12B on seizure susceptibility. Results: The MR results revealed a causal effect of IL-12B on GE (IVW: Conclusion: Our study demonstrated that elevated serum levels of IL-12B are associated with an increased risk of GE. The results were validated through
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