Evidence map›Paper›PMID 41607816›Full record

ArticleWorld journal of transplantation2026

Outcomes of basiliximab

Chukwuma A Chukwu, Philip A Kalra, Marcus Lowe, Kay Poulton, Titus Augustine, Anirudh Rao

Abstract read
In one paragraph

Article in World journal of transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Chukwuma A ChukwuDepartment of Nephrology, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, Mersey Side, United Kingdom. chukwuma.chukwu@rlbuht.nhs.uk.
Philip A KalraDepartment of Nephrology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester M6 8HD, Greater Manchester, United Kingdom.
Marcus LoweDepartment of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester M13 9PL, Greater Manchester, United Kingdom.
Kay PoultonDepartment of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester M13 9PL, Greater Manchester, United Kingdom.
Titus AugustineDepartment of Renal and Pancreatic Transplantation, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester M13 9PL, Greater Manchester, United Kingdom.
Anirudh RaoDepartment of Nephrology, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8YE, Mersey Side, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of induction immunosuppression agents has improved kidney transplant outcomes, but selecting the optimal agent remains a point of debate.

aimTo compare the long-term outcomes of kidney transplant recipients receiving alemtuzumab

methodsKidney transplant recipients who received alemtuzumab or basiliximab induction from 2014 to 2019 across two nephrology centres in Northwest England were evaluated. Propensity score matching at a 1:1.5 ratio ensured comparability between cohorts. Baseline characteristics, immunosuppression regimens, and outcomes were analyzed. Linear, binary logistics and Cox proportional hazard regression models.

resultsA total of 436 recipients were included, with a median follow-up of 5.2 years. The matched cohort (

conclusionIn this propensity score-matched analysis, alemtuzumab induction was associated with lower graft function at 12 months and higher risks of viral infection, post-transplant malignancy, and graft loss compared with basiliximab. These findings highlight the need for further studies to confirm the long-term safety and effectiveness of alemtuzumab in kidney transplantation.

Indexed as

AlemtuzumabBasiliximabGraft outcomesImmunosuppression inductionKidney transplantation

Identifiers

PMID41607816
PMCPMC12836231

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.