ArticleFrontiers in immunology2025
Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Immunotherapy rechallenge in gastric cancer: resistance mechanisms, molecular stratification, and precision decision-making.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Immune checkpoint inhibitors (ICIs) have demonstrated efficacy in the treatment of resectable and advanced gastric cancer. However, their effectiveness in initially unresectable gastric cancer remains unclear. This study aims to evaluate the efficacy and elucidate the molecular mechanisms of conversion therapy utilizing ICIs in patients with initially unresectable gastric cancer. Methods: This retrospective cohort study included patients with initially unresectable locally advanced or oligometastatic gastric cancer treated with ICIs-based therapy for conversion purposes. The primary endpoints were rates of complete pathological response (pCR), major pathological response (MPR), and R0 resection. Secondary endpoints included overall survival (OS), disease-free survival (DFS), event-free survival (EFS) and safety. A multi-omics analysis was performed on the tumor samples. Results: A total of 73 patients were analyzed, with 75.3% at stage cIV. The median EFS and OS were 26.1 and 41.3 months, respectively. 82.2% of the patients underwent radical surgery and achieved a median EFS of 30.9 months. The pCR and MPR rates were 24.7% and 37.0%, respectively. R0 resection was associated with superior survival, and MPR further enhanced efficacy. The incidence of adverse effects and postoperative complications were within acceptable limits. KMT2D mutations were associated with improved outcomes and enhanced immune responses, whereas tumor cytochrome P450 was linked to resistance. Conclusion: ICIs-based conversion therapy demonstrates promising survival benefits and manageable safety profiles for patients with unresectable locally advanced or oligometastatic gastric cancer, and provides real-world evidence for a potential treatment strategy. Additionally, multi-omics findings have revealed drug resistance mechanisms and potential biomarkers of efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.