ArticleFrontiers in immunology2025
Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Umbilical cord blood-derived CAR-NK cells: an emerging off-the-shelf platform for cancer immunotherapy.International journal of hematology · 2026Review
- Exploring CAR cell therapies beyond CAR-T for myeloid malignancies.Journal of biomedical science · 2026Review
- Engineering CLL-1 CAR-NK cells via mRNA-LNP for potent antitumor activity and reversal of HLA-E-mediated resistance in acute myeloid leukemia.Journal of experimental & clinical cancer research : CR · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
Introduction: Umbilical cord blood (UCB) is an attractive source of natural killer (NK) cells for the development of allogeneic 'off-the-shelf' cancer immunotherapies. This is due to the relatively high proportion of highly proliferative NK cells compared to adult peripheral blood (APB), a low risk of graft-versus-host disease and ease of procurement. However, due to the limited starting volume of UCB and naïve phenotype of isolated cells, Methods: To better characterize this variability, we measured UCB NK cell Results: Our results revealed that despite wide inter-donor variability in performance between CBUs, Conclusion: In conclusion, early isolation and cryopreservation of CD3
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