ReviewFrontiers in immunology2025
Bitter taste receptors in the gut-vascular axis: a novel target for immune and metabolic regulation of hypertension.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bitter Chinese Herbal Medicine Exerts Pharmacological Effects via TAS2Rs: A Systematic Review from Natural Ligands to Therapeutic Potential.International journal of molecular sciences · 2026Pooled it
- Beyond Sensory Properties: Molecular Interactions of Antioxidant Flavour-Active Polyphenols Across the Food-Oral-Gut Axis.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension affects approximately 1.3 billion adults worldwide, yet the control rate remains below 20%, highlighting the limitation of current therapies that primarily lower blood pressure without targeting the underlying pathophysiological mechanisms. Recent research indicates that bitter taste receptors, which are structurally distinct members of the G protein-coupled receptor superfamily, have functions that extend beyond their traditional role in oral taste perception. These receptors are extensively expressed along the gut-vascular axis, including in vascular smooth muscle, cardiac tissue, macrophages, and gastrointestinal organs, thereby positioning them as crucial nodes in the regulation of immunometabolic processes. This review systematically elucidates the complex regulatory mechanisms of gut-vascular axis TAS2Rs in the pathophysiology of hypertension and investigates TAS2R-targeting compounds, with particular emphasis on their effects in modulating blood pressure. This review consolidates evidence on TAS2R signaling across vascular, immune, and gastrointestinal interfaces to outline therapeutic implications for hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.