ArticleWorld journal of gastrointestinal oncology2026
Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients.
Article in World journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Sarcopenia Is Associated with Altered Rocuronium Onset and Neuromuscular Blockade Kinetics in Liver Transplant Recipients: A Prospective Observational Cohort Study.Journal of clinical medicine · 2026Article
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Abstract
backgroundPerioperative anesthesia management of obese patients presents significant challenges as traditional total body weight-based dosing fails to achieve optimal anesthetic effects due to altered pharmacokinetic characteristics including abnormal drug distribution and clearance. Rocuronium exhibits markedly different distribution patterns in obese patients, with conventional weight correction methods inadequately addressing individual muscle mass variations that critically influence drug distribution.
aimTo investigate the quantitative relationship between skeletal muscle index (SMI) and rocuronium distribution volume in obese colorectal cancer patients, establish a population pharmacokinetic model, and develop individualized dosing strategies based on muscle mass.
methodsA retrospective cohort study was conducted, including 100 obese patients (body mass index ≥ 30 kg/m
resultsAmong 100 patients, 35 (35.0%) had sarcopenia and 65 (65.0%) did not. Patients in the sarcopenia group were older (64.1 ± 9.8 years
conclusionSMI shows strong correlation with rocuronium distribution volume in obese colorectal cancer patients and is a key factor affecting drug distribution. SMI-based individualized dosing strategies can significantly improve target exposure achievement rate and reduce postoperative residual muscle relaxation incidence, providing scientific evidence for precision anesthesia management in obese patients.
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