Evidence map›Paper›PMID 41607618›Full record

ArticleWorld journal of cardiology2026

Nicotinamide adenine dinucleotide inhibits the production of reactive oxygen species and myocardial cell pyroptosis caused by hypoxia/re-oxygenation injury.

Shuang Dong, Yun-Qi Liu, Yi-Jun Tu, Shan Gao, Yu-Jie Liu, Chang Liu, Zuo-Wei Pei

Abstract read
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In one paragraph

Article in World journal of cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuang DongDepartment of Cardiology, Central Hospital of Dalian University of Technology, Dalian 116033, Liaoning Province, China.
Yun-Qi LiuCentral Laboratory, Central Hospital of Dalian University of Technology, Dalian 116033, Liaoning Province, China.
Yi-Jun TuDepartment of Pharmacy, Central Hospital of Dalian University of Technology, Dalian 116033, Liaoning Province, China.
Shan GaoCentral Laboratory, Central Hospital of Dalian University of Technology, Dalian 116033, Liaoning Province, China.
Yu-Jie LiuCentral Laboratory, Central Hospital of Dalian University of Technology, Dalian 116033, Liaoning Province, China.
Chang LiuCentral Laboratory, Central Hospital of Dalian University of Technology, Dalian 116033, Liaoning Province, China. liuch2024@dlut.edu.cn.
Zuo-Wei PeiDepartment of Cardiology, Central Hospital of Dalian University of Technology, Dalian 116033, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial ischemia/reperfusion (I/R) is a significant factor that negatively impacts the treatment outcomes of coronary heart disease, particularly acute myocardial infarction. The oxidized form of nicotinamide adenine dinucleotide (NAD) - NAD

aimTo explore the effects and mechanisms of NAD

methodsCell viability was assessed using the Cell Counting Kit-8 assay. Apoptosis in H9c2 cells was evaluated through terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling staining. Intracellular reactive oxygen species levels were measured with the fluorescent probe dichloro-dihydrofluorescein diacetate. Intracellular NAD

resultsThe study demonstrated that NAD

conclusionThese results indicate that NAD

Indexed as

Hypoxia/re-oxygenationIschemia/reperfusion injuryNicotinamide adenine dinucleotideOxidative stressPyroptosis

Identifiers

PMID41607618
PMCPMC12836013

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