Evidence map›Paper›PMID 41607489›Full record

ArticleJournal of human immunity2025

Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9

Pratibha Bhalla, Neha Ahuja, Ashwani Kumar, Chao Xing, Angela Moses, Ashutosh Shukla, Katelyn Boetel, Bret M Evers, John M Shelton, Maria Teresa de la Morena and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pratibha BhallaDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0001-6015-996X
Neha AhujaMolecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0003-0750-3383
Ashwani KumarEugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0009-0005-4330-5466
Chao XingEugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0002-1838-0502
Angela MosesDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0009-0009-3211-4356
Ashutosh ShuklaDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0002-7851-8817
Katelyn BoetelDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0009-0000-9951-5554
Bret M EversDepartment of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0001-5686-0315
John M SheltonDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0002-2949-1638
Maria Teresa de la MorenaDivision of Immunology, Department of Pediatrics, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0009-0003-6229-5465
Christian A WysockiDepartment of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0001-8035-8165
Ondine B CleaverMolecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0003-2454-6641
Nicolai S C van OersDepartment of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0002-6545-8405

Funding

INTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4M
Long noncoding RNAs and their contribution to 22q11.2 deletion syndromeR01AI114523 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VAN OERS, NICOLAI STANISLAS CYRILLE · 2015 to 2024
$4.1M
NIAID NIH HHS R01 AI114523NIAID NIH HHS T32 AI005284
6 · The paper itself

Abstract

Thymic hypoplasia, hypoparathyroidism, and cardiac defects are common congenital malformations caused by 22q11.2 deletion syndrome (22q11.2DS; aka DiGeorge syndrome). Thymus hypoplasia reduces peripheral T cell numbers, leading to more frequent infections. We report that embryonic hypoplastic thymuses from mouse models of 22q11.2DS (Tbx1

Identifiers

PMID41607489
PMCPMC12829771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.