ArticleFrontiers in endocrinology2025
Identifying metabolic parameters as key indicators of hyperuricemia and ischemic stroke comorbidity via interpretable Clinlabomics models.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Identification of key metabolic indicators associated with the comorbidity of ischemic stroke and diabetes mellitus using an optimal interpretable clinlabomics model.Frontiers in cardiovascular medicine · 2026Article
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9 authors.
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Abstract
Objective: Ischemic stroke (IS) with hyperuricemia (HUA) correlates with poor outcomes, yet the shared pathophysiological traits remain unclear. This study examined metabolic parameters in HUA-IS comorbidity and developed an optimal interpretable Clinlabomics model for risk assessment. Methods: A total of 2,164 IS patients and 2,459 healthy controls (HCs) were retrospectively enrolled. Participants were divided into four groups: HUA-IS (comorbidity, n=1,082), non-HUA IS (n=1,082), HUA HCs (n=1,314), non-HUA HCs (n=1,145); the latter three were defined as the non-comorbidity group. After 1:1 propensity score matching (PSM), 1,031 cases were matched in each group. Ten metabolic parameters were analyzed: serum uric acid at admission (SUA_admission), SUA on the third day of hospitalization (SUA_3d), triglyceride-glucose index (TyG), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), atherogenic index of plasma (AIP), atherogenic coefficient (AC), lipoprotein combine index (LCI), Castelli's risk index I (CRI-I), and Castelli's risk index II (CRI-II). Univariate/multivariate logistic regression, quartile-based logistic regression, and restricted cubic spline (RCS) analysis were used to explore parameters - comorbidity associations. Post-PSM data were split 7:3 into training/testing sets, least absolute shrinkage and selection operator (LASSO) regression selected features, and 11 machine learning algorithms developed Clinlabomics models. Additionally, the optimal model was validated in the testing set and an independent validation set. Results: After PSM, multivariate logistic regression identified AIP as the strongest risk factor (OR = 2.74, 95%CI: 1.80-4.19). The Q4 of TyG, TG, AIP, and LCI elevated comorbidity risk ( Conclusion: TyG, TG, AIP, and LCI were critical metabolic parameters for HUA-IS comorbidity, which warrant heightened attention in future comorbidity research.
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