Evidence map›Paper›PMID 41607420›Full record

ArticleResearch in pharmaceutical sciences2026

The effect of a multi-herbal product,

Hassan Yousefi-Mohammadabad, Mitra Abbasifard, Saiedeh Haji-Maghsoudi, Mahboobeh Raeiszadeh, Hossein Karegar-Borzi

Abstract read
In one paragraph

Article in Research in pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hassan Yousefi-MohammadabadPhysiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, I.R. Iran.
Mitra AbbasifardDepartment of Internal Medicine, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.
Saiedeh Haji-MaghsoudiModeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, I.R. Iran.
Mahboobeh RaeiszadehHerbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, I.R. Iran.
Hossein Karegar-BorziDepartment of Traditional Medicine, Faculty of Persian Medicine, Kerman University of Medical Sciences, Kerman, I.R. Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Osteoarthritis (OA) is a common joint disease that affects millions of people worldwide and is characterized by cartilage degeneration, stiffness, and limited mobility. This clinical trial aimed to investigate the efficacy and safety of a herbal combination of Experimental approach: Seventy patients diagnosed with knee OA were randomized to receive the herbal product or a placebo for 6 weeks. Pain and functional outcomes were measured using the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index and Visual Analogue Scale (VAS). The heel-to-thigh distance parameter was also assessed by measuring the distance between the thigh and heel at maximum knee flexion in the prone position. Findings/Results: Significant improvements were observed in WOMAC scores for pain, stiffness, and physical function in the herbal product group compared to placebo at 3 and 6 weeks. VAS scores confirmed these results and showed lower pain intensity in the herbal product group. Heel-to-thigh distance decreased significantly within all groups during the study. Conclusion and implications: This study provided evidence for the efficacy of the herbal combination in the management of knee OA symptoms and was well tolerated by all patients with no severe adverse effects. The observed benefits emphasized the potential of herbal medicines as a complementary approach in the management of knee OA. Further research is needed to fully elucidate the therapeutic mechanisms and optimize the clinical application of this herbal combination.

Indexed as

AshwagandhaAutumn crocusKnee osteoarthritisMasticPainPersian medicine

Identifiers

PMID41607420
PMCPMC12840866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.