ArticleInternational journal of preventive medicine2025
Mechanism of Antinociceptive Effect of Vanillin in Formalin Test.
Article in International journal of preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dried Ginger Milk Extract Alleviates Inflammatory Bowel Disease-Associated Bone Loss via Gut Microbiota-Metabolite Remodeling and MEK/ERK Inhibition.Pharmaceuticals (Basel, Switzerland) · 2026Article
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Authors and funding
3 authors.
Funding
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Abstract
Backgrounds: Vanillin is the active component of Methods: Male Swiss mice (25-30 g) were used. Formalin test was used to evaluate the antinociceptive effect. Different groups of mice were pretreated with prazocin (2 mg/kg), yohimbine (5 mg/kg), propranolol (2 mg/kg), cyproheptadine (2 mg/kg), ondansetron (2 mg/kg), naloxone (5 mg/kg), sulpiride (20 mg/kg), arginine (100 mg/kg), L-NAME (20 mg/kg), methylene blue (5 mg/kg), or glibenclamide (10 mg/kg) to evaluate the role of pertinent receptors or pathways on vanillin-induced antinociception. Results: Vanillin showed antinociceptive effect in the second phase of formalin test. Pretreatment with ondansetron, sulpiride, L-NAME, methylene blue, or glibenclamide prevented vanillin antinociceptive effect. Conclusions: Vanillin showed antinociceptive effect in formalin test, and according to the results, the NO/cGMP/K
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