SynthesisFrontiers in neuroscience2025
Associations between the brain glymphatic system and mitochondrial (dys)function: a systematic review.
Synthesis in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Elevated glutamine but not glutamate is associated with clozapine eligibility in an early psychosis sample.Frontiers in psychiatry · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Previous studies have shown that the proper functioning of both mitochondria and the glymphatic system transporting metabolites are essential for brain health. The aim of this systematic review was to identify the current evidence-based data regarding the relationship between mitochondria and the glymphatic system. Methods: This systematic review was conducted following PRISMA guidelines. The databases of PubMed, Scopus, Medline, and Web of Science were searched on June 11, 2024, for eligible studies published until June 1, 2024. Results: Of 103 studies, six were included: two original studies and four review articles. All the included studies consistently indicated that the mitochondria and the glymphatic system are likely interconnected, with evidence suggesting several potential links between them. According to original studies, mitochondrial abnormalities in idiopathic normal pressure hydrocephalus (iNPH) and idiopathic intracranial hypertension (IIH) may disrupt glymphatic system function. The included reviews highlighted REM sleep deprivation, melatonin, and inflammation as potential factors linking mitochondria and the glymphatic system. Discussion: The relationship between mitochondria and the glymphatic system is complex. Further research is needed to clarify the precise mechanisms of interaction as the current literature is largely speculative. Existing evidence suggests that mitochondrial abnormalities are present in iNPH and IIH, conditions related to impaired CSF flow and impaired glymphatic function. In addition, sleep and melatonin potentially link mitochondrial activity and the glymphatic system function and thus offer potential avenues to ameliorate disorders associated with glymphatic dysfunction by enhancing mitochondrial activity.
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