Evidence map›Paper›PMID 41607402›Full record

ArticleFrontiers in neuroscience2025

Altered static and dynamic amplitude of low-frequency fluctuations in acute carbon monoxide poisoning patients: a resting-state fMRI study.

Shenghai Wang, Tianze Sun, Wenxuan Han, Xiaoying Lin, Jiaqi Zhang, Yihao Peng, Mingyue Ma, Wei Sheng, Ming Zhang, Haining Li

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Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Shenghai WangDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Tianze SunDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wenxuan HanDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiaoying LinDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jiaqi ZhangDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yihao PengDepartment of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Mingyue MaDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wei ShengMR Research Collaboration, Siemens Healthineers, Shanghai, China.
Ming ZhangDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Haining LiDepartment of PET/CT, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to investigate alterations in brain activity due to acute carbon monoxide poisoning (ACOP) and their relationship with clinical manifestations using static and dynamic amplitude of low-frequency fluctuation (ALFF) analyses. Methods: Resting-state functional magnetic resonance imaging (fMRI) and clinical data were obtained from 31 ACOP patients and 28 healthy controls. The static ALFF value and dynamic ALFF variability were measured and compared between groups. Partial correlation analysis explored the relationships between changes in ALFF and clinical features in ACOP patients. Results: ACOP patients exhibited increased dynamic ALFF in the bilateral superior frontal gyrus (SFG) and left middle frontal gyrus (MFG) and decreased static ALFF in the left middle occipital gyrus (MOG) compared to controls. Aberrant dynamic ALFF in the left SFG and MFG was negatively correlated with MoCA-B scores ( Conclusion: ACOP patients exhibited abnormal instability in intrinsic brain activity, particularly in prefrontal areas, where temporal variability in local brain activity correlates with cognitive performance. This study highlights the value of combined static and dynamic ALFF approaches in understanding brain disturbances caused by CO exposure, providing new insights into the neuropathological mechanisms of ACOP.

Indexed as

carbon monoxide poisoningcognitive functiondynamic amplitude of low-frequency fluctuationintrinsic brain activityresting-state functional magnetic resonance imaging

Identifiers

PMID41607402
PMCPMC12835238

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