Evidence map›Paper›PMID 41607394›Full record

ReviewWorld journal of gastrointestinal endoscopy2026

Endoscopic submucosal dissection: Challenges, innovations, and the road ahead.

Miltiadis K Moutzoukis, Anastasios Manolakis, Andreas Kapsoritakis, Dimitrios Christodoulou, Konstantinos Argyriou

Abstract readReview
In one paragraph

Review in World journal of gastrointestinal endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miltiadis K MoutzoukisDepartment of Gastroenterology, University Hospital of Ioannina, Ioannina GR45333, Greece.
Anastasios ManolakisDepartment of Gastroenterology, University Hospital of Larisa, Larisa 41100, Greece.
Andreas KapsoritakisDepartment of Gastroenterology, University Hospital of Larisa, Larisa 41100, Greece.
Dimitrios ChristodoulouDepartment of Gastroenterology, Medical School and University Hospital of Ioannina, Ioannina GR45500, Greece.
Konstantinos ArgyriouDepartment of Gastroenterology, University Hospital of Larisa, Larisa 41100, Greece. kosnar2@yahoo.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoscopic submucosal dissection (ESD) offers a curative, organ-preserving approach for early-stage gastrointestinal tumors, yet its global adoption remains inconsistent. This review examined the multifaceted challenges hindering wider use of ESD, including the steep technical learning curve, variability in training access, procedural time demands, and risk of complications. We explored recent innovations aimed at improving procedural outcomes and reducing operator dependency, such as enhanced dissection tools, traction techniques, and digital training platforms. In addition, emerging technologies, such as artificial intelligence, robotics, and image-guided systems, are reshaping the procedural landscape and may help streamline both decision-making and execution. Looking forward, addressing the current limitations of ESD will require technical refinement as well as broader investment in training infrastructure and system-level support. This article outlined key areas for development and provided a forward-looking perspective on how ESD may evolve into a more accessible and standardized therapeutic modality.

Indexed as

Endoscopic submucosal dissectionFuture directionsGastrointestinal neoplasmsLearning curveTechnological innovationTreatment outcome

Identifiers

PMID41607394
PMCPMC12836162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.