ArticleWorld journal of gastrointestinal endoscopy2026
Comparative outcomes of laparoscopic
Article in World journal of gastrointestinal endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundPancreaticoduodenectomy (PD) represents the standard surgical approach for resectable pancreatic ductal adenocarcinoma (PDAC); however, its high morbidity has prompted the exploration of minimally invasive alternatives. While laparoscopic PD (LPD) has demonstrated promise, evidence comparing LPD and open PD (OPD) in early-stage PDAC remains limited.
aimTo compare the perioperative and oncologic outcomes of LPD and OPD in patients with early-stage PDAC.
methodsThis retrospective propensity-matched analysis included 100 patients with stage I-II PDAC who underwent curative PD between January 2022 and December 2024. Patients were matched 1:1 for age, sex, body mass index, American Society of Anesthesiologists score, and tumor stage. Perioperative outcomes assessed included operative time, blood loss, transfusion rate, hospital stay, complications (overall, severe, pancreatic fistula, delayed gastric emptying, wound infection, intra-abdominal abscess, bile leak, pulmonary complications, and sepsis), and enhanced recovery after surgery metrics (time to mobilization, oral intake, and pain scores). Oncologic outcomes included lymph node yield, R0 resection rate, recurrence-free survival, and overall survival (OS).
resultsCompared with OPD, LPD was associated with reduced intraoperative blood loss [median 170 mL (interquartile range: 130-220 mL)
conclusionLPD offers perioperative benefits, including reduced blood loss, fewer transfusions, shorter hospital stays, and improved recovery metrics, without compromising oncologic outcomes in early-stage PDAC. These findings support its selective use in high-volume centers with experienced surgeons, promoting faster recovery while maintaining long-term efficacy.
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