Evidence map›Paper›PMID 41607332›Full record

ArticleJournal of oral & facial pain and headache2026

HCN2 channels: a potential therapeutic target for orofacial neuropathic pain after trigeminal nerve injury.

Toru Yamamoto, Tomoaki Ujita, Yurie Sato-Yamada, Takako Ichiki, Naotaka Kishimoto, Miho Terunuma, Kenji Seo

Abstract read
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In one paragraph

Article in Journal of oral & facial pain and headache, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Toru YamamotoDivision of Dental Anesthesiology, Faculty of Dentistry & Graduate School of Medicine and Dental Sciences, Niigata University, 951-8514 Niigata, Japan.ORCID 0000-0002-2464-4236
Tomoaki UjitaDivision of Dental Anesthesiology, Faculty of Dentistry & Graduate School of Medicine and Dental Sciences, Niigata University, 951-8514 Niigata, Japan.ORCID 0000-0003-0499-923X
Yurie Sato-YamadaCenter for Advanced Oral Science, Faculty of Dentistry & Graduate School of Medicine and Dental Sciences, Niigata University, 951-8514 Niigata, Japan.ORCID 0000-0002-0515-1807
Takako IchikiDepartment of Oral Biochemistry, Faculty of Dentistry & Graduate School of Medicine and Dental Sciences, Niigata University, 951-8514 Niigata, Japan.ORCID 0000-0002-8670-9541
Naotaka KishimotoDivision of Dental Anesthesiology, Faculty of Dentistry & Graduate School of Medicine and Dental Sciences, Niigata University, 951-8514 Niigata, Japan.ORCID 0000-0002-8716-5056
Miho TerunumaDepartment of Oral Biochemistry, Faculty of Dentistry & Graduate School of Medicine and Dental Sciences, Niigata University, 951-8514 Niigata, Japan.ORCID 0000-0003-1876-9726
Kenji SeoDivision of Dental Anesthesiology, Faculty of Dentistry & Graduate School of Medicine and Dental Sciences, Niigata University, 951-8514 Niigata, Japan.ORCID 0000-0001-9126-9344

Funding

JSPS KAKENHI 23K09350; 19K10261; 22K19615
6 · The paper itself

Abstract

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have recently emerged as promising targets for the treatment of neuropathic pain. This study investigated the potential involvement of HCN2 channels in the development of trigeminal neuropathic pain following peripheral nerve injury. Infraorbital nerve chronic constriction injury (ION-CCI) model was adopted to rats, and head withdrawal thresholds (HWT) to mechanical stimulation were assessed pre- and postoperatively, as well as after pharmacological intervention. In the trigeminal ganglion (TG), intracellular cyclic adenosine monophosphate (cAMP) and cytoplasmic protein kinase A (PKA) levels were quantified by Enzyme-Linked Immunosorbent Assay (ELISA), while

Indexed as

Facial PainHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNeuralgiaPotassium ChannelsTrigeminal Nerve InjuriesAnimalsCyclic AMPCyclic AMP-Dependent Protein KinasesDisease Models, AnimalMaleRatsRats, Sprague-DawleyTrigeminal GanglionCyclic AMPCyclic AMP-Dependent Protein KinasesHcn2 protein, ratHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium ChannelsHyperpolarization-activated cyclic nucleotide-gated channelNeuropathic painOrofacialRatTrigeminal

Identifiers

PMID41607332
PMCPMC12853158

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.