Evidence map›Paper›PMID 41607294›Full record

ArticleEnvironmental toxicology2026

Ameliorating Effect of Continuous Treatment With an Amorphous Formula of Curcumin on Maternal Imidacloprid Exposure-Induced Suppression of Hippocampal Neurogenesis in Rats.

Yuri Ebizuka, Xinyu Zou, Nanami Watanabe, Mai Hirata, Susumu Yamashita, Tetsuhito Kigata, Qian Tang, Tomohiro Nakao, Mihoko Koyanagi, Makoto Shibutani

Abstract read
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In one paragraph

Article in Environmental toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuri EbizukaLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Xinyu ZouLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8551-9319
Nanami WatanabeLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Mai HirataLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Susumu YamashitaLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Tetsuhito KigataCooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2219-9634
Qian TangGeneral Toxicology Department, TriApex Laboratories Co., Ltd., Nanjing, Jiangsu, China.ORCID https://orcid.org/0009-0001-8369-9798
Tomohiro NakaoEmulsion Laboratory, San-Ei Gen F.F.I., Inc., Osaka, Japan.ORCID https://orcid.org/0009-0009-1667-2307
Mihoko KoyanagiGlobal Safety and Regulatory Sciences, San-Ei Gen F.F.I., Inc., Osaka, Japan.ORCID https://orcid.org/0000-0003-2944-2438
Makoto ShibutaniLaboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.ORCID https://orcid.org/0000-0003-3417-9697

Funding

San-Ei Gen F.F.I., Inc.
6 · The paper itself

Abstract

Maternal exposure to imidacloprid (IMI) suppresses hippocampal neurogenesis in rat offspring. This study investigated the antioxidant effects of an amorphous formula of curcumin (CUR) given at a supplement level on IMI-induced suppression of neurogenesis to clarify the toxicity mechanisms. Maternal rats were given a diet containing 750-ppm IMI and drinking water with or without 120-ppm CUR from gestational day (GD) 6 until weaning at 21 days post-delivery. Then, offspring received CUR similarly until postnatal day 77 in adulthood. At weaning, IMI had suppressed neurogenesis and synaptic plasticity in granule cells, which may be related to suppressed reelin and parvalbumin signaling of GABAergic interneurons. IMI exposure increased CD68

Indexed as

CurcuminHippocampusInsecticidesNeonicotinoidsNeurogenesisNitro CompoundsPrenatal Exposure Delayed EffectsAnimalsAntioxidantsFemaleMaleMaternal ExposureNeuronal PlasticityOxidative StressPregnancyRatsAntioxidantsCurcuminimidaclopridInsecticidesNeonicotinoidsNitro CompoundsReelin ProteinReln protein, ratamorphous formula of curcumin (CUR)hippocampal neurogenesisimidacloprid (IMI)oxidative stresssynaptic plasticity

Identifiers

PMID41607294
PMCPMC13537361

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.