Evidence map›Paper›PMID 41607036›Full record

ArticleThe American journal on addictions2026

Brief report: Ketamine-assisted "bridge therapy" for opioid tapering in complex cases.

Mariana C de Oliveira, Cláudia C de Araujo Palmeira, André B Negrão, Ziyad A Hadi, Julia R Arana, Rita de Cássia Ferreira Duarte, Joice L P da Silva, Gustavo K Matsui, João F D Rapozero, Douglas H Crispim and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal on addictions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mariana C de OliveiraInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-6195-3716
Cláudia C de Araujo PalmeiraInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
André B NegrãoInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
Ziyad A HadiInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
Julia R AranaInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
Rita de Cássia Ferreira DuarteInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
Joice L P da SilvaInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
Gustavo K MatsuiInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
João F D RapozeroInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
Douglas H CrispimInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
André MalbergierInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
João M Castaldelli-MaiaInstituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOpioid use disorder (OUD) presents major challenges, especially when combined with chronic pain and psychiatric comorbidities. A 25-year-old woman with OUD, chronic pain, and major depressive disorder underwent an 8-week protocol of intravenous ketamine infusions (0.5 mg/kg weekly) as an adjunct to opioid tapering.

resultsMethadone dosage was reduced by 50%, with improved pain and craving control, reduced withdrawal symptoms, and greater psychotherapy engagement. DISCUSSION AND

conclusionsKetamine-assisted "bridge therapy" treatment may support opioid tapering in complex cases. SCIENTIFIC SIGNIFICANCE: This is a novel report to document a multifaceted improvement in this specific comorbidity cluster.

Indexed as

Analgesics, OpioidChronic PainDrug TaperingKetamineMajor Depressive DisorderOpioid-Related DisordersAdultBridge TherapyFemaleHumansMethadoneOpiate Substitution TreatmentAnalgesics, OpioidKetamineMethadone

Identifiers

PMID41607036
PMCPMC13108631

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.