ArticleEuropean journal of medical research2026
Beyond triorchidism: diagnostic pitfalls and an evidence-driven algorithm for pediatric supernumerary testes.
Article in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo characterize the clinical and imaging features of pediatric supernumerary testes (SNTs), a rare congenital anomaly also referred to as polyorchidism, to assess the diagnostic performance and misdiagnosis rate of ultrasonography and MRI, to identify factors associated with ultrasound misdiagnosis and surgical decision-making, and to develop an evidence-based management algorithm.
methodsWe conducted a retrospective review of two tertiary centers and a PRISMA-guided systematic review and pooled analysis (Jan 2000-Apr 2025; PROSPERO CRD420251000331) of pediatric cases, extracting data on presentation, imaging use, Bergholz classification, treatments, pathology, and factors associated with ultrasonographic misdiagnosis and surgical decision-making.
resultsIn our cohort (n = 22; median age 6 years), 10 (45.46%) were left-sided, 19 (86.36%) scrotal, 17 (77.27%) presented with a painless scrotal mass; ten had concomitant urogenital anomalies; Bergholz type A3 accounted for 8 (36.36%). Six patients underwent surgery, which was associated with extrascrotal location and higher decision-regret scores (P < 0.05). Pooled analysis (n = 113 patients, 127 SNTs) showed 101 (89.38%) of triorchidism, 71 (62.83%) left-sided, and 62.21% (79/127) scrotal; Bergholz type A3 comprised 29.13% (37/127) and type B comprised 16.54% (21/127); ultrasonography was used in 81 (71.68%) cases and MRI in 20 (17.70%), with a misdiagnosis rate of 22.22% (18/81), which was significantly associated with younger age, extrascrotal site, greater distance from orthotopic testis, and concomitant anomalies (P < 0.05). Asymptomatic presentations accounted for 41 (36.28%). Common comorbidities included cryptorchidism, inguinal hernia, and torsion. Treatments were orchiopexy in 48 (42.48%), orchiectomy in 32 (28.32%), observation in 30 (26.55%); none of 53 postoperative pathologies were malignant. Surgical patients tended younger, with more extrascrotal SNTs and symptomatic or complicated presentations (P < 0.05); observation was associated with higher ultrasonography and MRI use (P < 0.001). Sensitivity analyses using a combined dataset yielded consistent results, supporting the robustness of the primary findings.
conclusionsPediatric SNTs are rare and often accompanied by urogenital malformations. Ultrasonography is the mainstay imaging modality but has notable misdiagnosis risk in younger, extrascrotal, distant, or obese patients. Conservative management is preferred in the absence of malignancy; whereas prompt surgery is indicated for extrascrotal location, cryptorchidism, torsion, or complications.
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