Evidence map›Paper›PMID 41606719›Full record

ArticleBMC infectious diseases2026

The increased detection of recombinant norovirus GII.4 Sydney_2012[P16] strains in hospitalized pediatric patients with gastroenteritis in Shanghai, China.

Fangyuan Yu, Xuhua Feng, Haiqin Ye, Qin Cai, Jie Jiang, Tiandong Zhang, Fen Pan, Wenhao Weng

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Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Fangyuan YuDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xuhua FengDepartment of Clinical Laboratory, Shanghai Geriatric Medical Center, Shanghai, China.
Haiqin YeDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Qin CaiDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jie JiangDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Tiandong ZhangDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Fen Pan *Department of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wenhao Weng *Department of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wengwenhao@shchildren.com.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo understand the genetic diversity and recombination of norovirus infection in children with hospital-acquired acute gastroenteritis in Shanghai, and to provide a scientific basis for the prevention of norovirus infection in hospitalized children.

methods12,485 stool specimens of children with hospital-acquired acute gastroenteritis were collected from October 2018 to June 2021. Gene amplification and sequencing of VP1, RdRp and RdRp-VP1 region were performed on norovirus-positive specimens using RT-PCR method. Genotyping and recombination analysis of sequenced sequences were performed using online analysis tools.

resultsThe positive rate of norovirus infection in children with hospital-acquired diarrhea by real-time quantitative RT-PCR was 16.2% (2,017/12,485). Based on the gene sequencing analysis of norovirus across the RdRp-VP1 region, nine norovirus recombinant strains were detected. From October 2018 to September 2020, the proportion of norovirus GII.4 Sydney_2012[P31] was 56.5% (231/409), while the proportion of GII.4 Sydney_2012[P16] was only 1.2% (5/409) in the same period. However, from October 2020 to June 2021, the detection rate of the recombinant strain GII.4 Sydney_2012[P16] increased to 38.8% (57/147), which exceeded that of the recombinant strain GII.4 Sydney_2012[P31] (19.0%, 28/147).

conclusionsNorovirus GII.4 Sydney_2012 remained the main prevalent genotype, but the recombinant strain of GII.4 Sydney_2012[P16] had an increased positivity rate since October 2020. It is imperative that surveillance and management of hospital-acquired norovirus acute gastroenteritis in hospitalized children be strengthened to prevent nosocomial norovirus outbreaks.

Indexed as

Caliciviridae InfectionsCross InfectionGastroenteritisNorovirusChildChild, HospitalizedChild, PreschoolChinaFecesFemaleGenetic VariationGenotypeHumansInfantMalePhylogenyAcute gastroenteritisChildrenNorovirusRecombinants

Identifiers

PMID41606719
PMCPMC12924388

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