Evidence map›Paper›PMID 41606678›Full record

ArticleCell & bioscience2026

Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila.

Shuliu Zhang, Sifan Gong, Yiming Yang, Wenting Gong, Qingxia Zhou, Kun Yang, Menglong Rui, Su Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuliu Zhang *School of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Institute of Microphysiological Systems, Southeast University, Nanjing, 210096, China.
Sifan Gong *School of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Institute of Microphysiological Systems, Southeast University, Nanjing, 210096, China.
Yiming YangSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Institute of Microphysiological Systems, Southeast University, Nanjing, 210096, China.
Wenting GongSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Institute of Microphysiological Systems, Southeast University, Nanjing, 210096, China.
Qingxia ZhouSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Institute of Microphysiological Systems, Southeast University, Nanjing, 210096, China.
Kun YangDepartment of Neurosurgery, Zhongda Hospital, Southeast University, Nanjing, 210096, China. yungkun@126.com.
Menglong RuiSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Institute of Microphysiological Systems, Southeast University, Nanjing, 210096, China. ruimenglong@seu.edu.cn.
Su WangSchool of Life Science and Technology, Key Laboratory of Development Genes and Human Disease, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Institute of Microphysiological Systems, Southeast University, Nanjing, 210096, China. wangsu@seu.edu.cn.ORCID https://orcid.org/0000-0002-3167-6420

Funding

Medical Science and Technology Development Foundation of Nanjing ZKX22041Ministry of Science and Technology of the People's Republic of China 2021ZD0204000Research Personnel Cultivation Programme of Zhongda Hospital Southeast University CZXM-GSP-RC-152the National Natural Science Foundation of China 52033002Zhongda Hospital Affiliated to Southeast University, Jiangsu Province High-Level Hospital Pairing Assistance Construction Funds zdlyg05
6 · The paper itself

Abstract

Most neural stem cells (NSCs) maintain self-renewal to ensure proper development of central nervous system (CNS) until a specific time and undergo terminal differentiation after neurogenesis. However, the regulation of the NSC maintenance during brain development is not well understood. Our study reveals that casein kinase 2 (CK2) is essential for maintaining NB self-renewal in late larval stages in Drosophila. Deficiency of CK2 results in increased nuclear localization of the differentiation promoting factor Prospero (Pros), and consequently a significant reduction in NB number. Mechanistically, Pros is phosphorylated by CK2 and sequestered in the cytoplasm, which prevents premature differentiation of the NB in late larval stages. While in pupal stages, the developmentally declined expression of CK2 allows NBs to undergo terminal differentiation. Overall, our study uncovers a critical role of CK2 as a time switch on NB transition from self-renewal to differentiation, highlighting a novel mechanism of the temporal regulation of neurogenesis by post-translational modifications (PTMs).

Identifiers

PMID41606678
PMCPMC12922212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.