ArticleJournal of medical case reports2026
A complete pathological response to preoperative chemotherapy in a male patient with primary neuroendocrine breast cancer: a case report.
Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrimary neuroendocrine carcinoma (small-cell carcinoma) of the breast is a rare tumor; most cases are reported in women. Small-cell carcinoma is a type of neuroendocrine tumor characterized by high-grade, poorly differentiated, and aggressive behavior, which are common features regardless of the tumor's location. Here, we present a rare case of primary small-cell carcinoma of the breast in a male patient treated successfully with neoadjuvant chemotherapy followed by surgery. CASE PRESENTATION: A 47-year-old Syrian man presented with a left breast mass. Further histopathological investigation revealed the diagnosis of high-grade small-cell carcinoma of the breast. Computed tomography imaging excluded other potential primary origins. The patient was treated with neoadjuvant chemotherapy (cisplatin and etoposide), followed by a modified radical mastectomy. After 18 months of diagnosis, the patient is under surveillance and doing well.
conclusionThis report presents a rare case of male breast cancer with the uncommon histological diagnosis of small-cell carcinoma. It highlights a successful therapeutic approach in the absence of established treatment guidelines.
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