Evidence map›Paper›PMID 41606567›Full record

ArticleBMC pulmonary medicine2026

Indwelling pleural catheter efficacy and safety in malignant vs. non-malignant pleural effusions: a prospective study.

Hossein Kazemi Zadeh, Ramyar Mahdavi, Niloofar Khoshnam Rad, Aryan Shirani, Hamidreza Abtahi, Sedigheh Mozaffari, Krupa Solanki, Ghazal Roostaei

Abstract read
In one paragraph

Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hossein Kazemi ZadehThoracic Research Centre, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Ramyar MahdaviUniversity of Southern California (USC), Los Angeles, CA, USA.
Niloofar Khoshnam RadThoracic Research Centre, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Aryan ShiraniDepartment of Internal Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Hamidreza AbtahiThoracic Research Centre, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Sedigheh MozaffariThoracic Research Centre, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Krupa SolankiUniversity of Southern California (USC), Los Angeles, CA, USA.
Ghazal RoostaeiThoracic Research Centre, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Roostaei.ghazal@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndwelling pleural catheters (IPCs) are used to manage refractory pleural effusions (PEs), including malignant (MPE) and non-malignant pleural effusions (NMPE). This study evaluates IPC efficacy and safety, focusing on pleurodesis success, symptom relief, recurrence, survival, and complications.

methodsA prospective cohort study of 74 patients (62 MPE, 12 NMPE) who underwent IPC insertion between 2019 and 2024 at a tertiary teaching hospital. Patients were followed for at least 12 months. The primary outcomes were symptom relief and successful pleurodesis. Secondary outcomes included the duration of IPC placement, time to pleurodesis, recurrence rates, complication rates, and overall survival.

resultsPleurodesis was achieved in 32% of patients, lower in MPEs (28%) than NMPEs (50%) (p = 0.02). Mean IPC duration was 10.2 weeks (MPE: 10.7, NMPE: 7.5 weeks). Symptom relief was reported in 85%, with no significant difference between groups. Recurrence occurred in 3% of patients, all within the NMPE cases. Complications included catheter blockage (16%), chest pain (13%), loculation (9%), and pleural infection (9%), with no significant differences between groups. MPE patients had significantly lower survival at 3, 6, and 12 months (p < 0.05). IPC duration was not linked to survival (p = 0.93).

conclusionIPCs provide symptom relief and facilitate pleurodesis, though success is lower in MPEs. Complications are comparable between groups, supporting IPCs as a management option for both MPE and NMPE. Further research is needed to optimize IPC use and identify predictors of pleurodesis success.

trial registrationRetrospectively registered.

Indexed as

Catheters, IndwellingPleural EffusionPleural Effusion, MalignantPleurodesisAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesRecurrenceTreatment OutcomeIndwelling pleural catheterMalignant pleural effusionNon-malignant pleural effusionPleurodesisSurvival

Identifiers

PMID41606567
PMCPMC12924537

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.