ArticleBMC medical imaging2026
Establishing T1 and ECV mapping based nomogram differentiate acute ischemic and nonischemic myocardial injury: a proof-of-concept study.
Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Role of the Extracellular Volume of the Infarction Zone and the Remote Myocardium in Predicting Systolic Dysfunction After the First Myocardial Infarction.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
16 authors.
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Abstract
objectivesTo develop and validate a nomogram based on T1 and extracellular volume fraction (ECV) mapping derived from cardiovascular magnetic resonance (CMR) for differentiating ischemic from nonischemic cardiomyopathies during the acute phase.
methodsThis retrospective study included patients who underwent CMR at the Fifth Affiliated Hospital of Wenzhou Medical University (internal dataset) and the Fifth Affiliated Hospital of Sun Yat-sen University (external dataset). Patients were assigned to a training set (n = 73), a test set (n = 30), an internal validation set (n = 28), and an external validation set (n = 16). Six multivariable logistic regression models were constructed to predict acute nonischemic myocardial injury (NMI), and the best-performing model was selected to create an interactive online nomogram accessible via a dedicated webpage.
resultThe optimal model incorporated coronary stenosis, hypertension, ejection fraction (EF), myocardial salvage index (MSI), T1 native non-edema, and ECV edema. It demonstrated strong predictive performance in the training set (AUC 0.970, 95% CI 0.938-0.989), test set (AUC 0.902, 95% CI 0.789-0.954), internal validation set (AUC 0.839, 95% CI 0.668-0.907), and external validation set (AUC 0.767, 95% CI 0.520-0.936). The model also showed excellent calibration and potential clinical utility.
conclusionsIn acute myocardial injury, increased T1 native non-edema values and reduced ECV edema values are indicative of NMI. The proposed nomogram demonstrated good generalizability and robustness, particularly in complex clinical scenarios, and offers promising potential for clinical application.
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