SynthesisBMC infectious diseases2026
Pneumococcal vaccine for prevention of acute otitis media in children: a meta-analysis.
Synthesis in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
Streptococcus pneumoniae-induced acute otitis media (AOM) continues to be a leading infectious disease among children, despite the introduction of pneumococcal conjugate vaccines (PCV). The effectiveness of pneumococcal vaccines in preventing AOM, as well as their impact on clinical manifestations and complications, remains a subject of debate. This meta-analysis aimed to assess the efficacy of pneumococcal vaccines, along with associated symptoms and complications. A comprehensive search was conducted across PubMed, Embase, Cochrane Library, and Web of Science for studies published between 2012 and 2024. The quality of the included studies was assessed using the Cochrane Risk of Bias tool, and statistical analysis was performed using StataMP18. The analysis included eleven studies encompassing 1,331,407 individuals. The results revealed that the experimental group exhibited a significant increase in the incidence of fever (≥ 38.5 °C) [RR = 1.370, 95% CI (1.272, 1.467), P < 0.001], as well as a significantly higher incidence of recurrent acute otitis media [RR = 1.053, 95% CI (1.040, 1.065), P < 0.001]. In conclusion, PCV may have limited efficacy in preventing AOM in certain pediatric subpopulations and settings, with substantial between-study heterogeneity.
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