Evidence map›Paper›PMID 41606493›Full record

SynthesisBMC anesthesiology2026

Effects of EEG-guided anesthetic depth monitoring on delirium incidence across different age groups: a systematic review and meta-analysis.

YanRui Chen, Yue Zou, XinYu Zhao, Lei Zhang

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07533370 (Extended Emergence Trajectory on Post-Anesthesia Care Units Events in Ambulatory Lower-Extremity Orthopedic Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07533370 nanot yet recruitingnot on this map

Extended Emergence Trajectory on Post-Anesthesia Care Units Events in Ambulatory Lower-Extremity Orthopedic Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorHarrison Shong-Wen ChowRan2026 to 2027Enrolled300ConditionsPerioperative Care, EEG Power Spectra, Delirium - PostoperativeArmsStandard of Care EEG-Guided Emergence, Extended EEG Emergence Trajectory
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

YanRui ChenDepartment of Anesthesiology, Beijing Luhe Hospital, Capital Medical University, Beijing, 101199, China.
Yue ZouDepartment of Anesthesiology, Beijing Luhe Hospital, Capital Medical University, Beijing, 101199, China.
XinYu ZhaoDepartment of Critical Care Beijing Lu He hospital, Capital Medical University, Beijing, 101149, China.
Lei ZhangDepartment of Critical Care Beijing Lu He hospital, Capital Medical University, Beijing, 101149, China. 13932647061@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative delirium (POD) and emergence delirium (ED) commonly occur in elderly and pediatric patients undergoing anesthesia. Electroencephalography (EEG)-based monitoring technologies, including Bispectral Index (BIS), SedLine EEG monitoring, and other EEG techniques, have been proposed as potential strategies for reducing delirium risk, but current evidence remains controversial. Therefore, this systematic review and meta-analysis aimed to evaluate the impact of EEG-guided anesthesia on delirium incidence in patients of various age groups.

methodsPubMed, Embase, Web of Science, and the Cochrane Library were searched upto August 2025 for studies investigating EEG-guided anesthesia depth and delirium outcomes. The primary outcomes included incidence of POD and Pediatric Anesthesia Emergence Delirium (PAED) scores. Meta-analysis and subgroup analyses based on EEG monitoring techniques were conducted using Stata software. Publication bias was assessed with Begg's and Egger's tests.

resultsTwenty studies involving 7344 adult patients and 463 pediatric patients were included. Pooled analyses indicated that deep anesthesia significantly increased POD risk in elderly patients (P = 0.008). For adult patients, EEG-guided anesthesia was associated with a significant reduction in POD compared with usual care (P = 0.001). In elderly patients, EEG-guided anesthesia was associated with a non-significant trend toward lower postoperative delirium (P = 0.123). For pediatric patients, EEG monitoring did not significantly affect PAED scores overall (P = 0.143); however, subgroup analysis revealed that non-BIS modality may have reduced PAED scores (P < 0.001).

conclusionsThe effectiveness of EEG-guided anesthesia in reducing delirium risk varies across age groups. EEG monitoring effectively decreases POD incidence in adults. Among elderly patients, EEG-guided anesthesia did not significantly reduce the risk of POD, whereas non-BIS modality may confer greater benefit for pediatric emergence delirium. These findings are hypothesis-generating; future studies should define age-tailored EEG monitoring strategies and clarify indications across patient groups.

Indexed as

AnesthesiaDeliriumElectroencephalographyEmergence DeliriumPostoperative ComplicationsAgedAge FactorsChildHumansIncidencePediatric AnesthesiaAnesthesia depthBispectral indexEEG monitoringEmergence deliriumMeta-analysisPostoperative delirium

Identifiers

PMID41606493
PMCPMC12955314

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.