Evidence map›Paper›PMID 41606394›Full record

ArticleArchives of toxicology2026

Assessment of endocrine disruptor impact on carbohydrate metabolism in the HepaRG human hepatic cell line.

Kévin Bernal, Arnaud Tête, Béatrice Le-Grand, Patrick Balaguer, Min Ji Kim, Xavier Coumoul, Etienne B Blanc

Abstract read
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In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kévin BernalUniversité Paris Cité, INSERM, Health & Functional Exposomics - HealthFex, 75006, Paris, France.ORCID 0009-0009-5565-2675
Arnaud TêteUniversité Paris Cité, INSERM, Health & Functional Exposomics - HealthFex, 75006, Paris, France.ORCID 0000-0002-1097-3944
Béatrice Le-GrandUniversité Paris Cité, INSERM, Health & Functional Exposomics - HealthFex, 75006, Paris, France.
Patrick BalaguerIRCM (Institut de Recherche en Cancérologie de Montpellier), Inserm U1194, Univ Montpellier, ICM, Montpellier, France.ORCID 0000-0002-3524-3622
Min Ji KimBobigny, HealthFEX, Inserm UMR-S 1124, Sorbonne Paris Nord University, 45 rue des Saints-Pères, Paris, France.
Xavier CoumoulUniversité Paris Cité, INSERM, Health & Functional Exposomics - HealthFex, 75006, Paris, France.ORCID 0000-0003-2928-9648
Etienne B BlancUniversité Paris Cité, INSERM, Health & Functional Exposomics - HealthFex, 75006, Paris, France. etienne.blanc@u-paris.fr.ORCID 0000-0002-3348-4772

Funding

ANSES EST-2014/1/156.H2020 Societal Challenges 825712
6 · The paper itself

Abstract

Endocrine-disrupting chemicals (EDCs) are increasingly implicated in the development of metabolic disorders such as type 2 diabetes mellitus (T2DM). As hepatic dysfunction is a hallmark of early metabolic disease, we investigated how EDCs may contribute to glucose dysregulation using human HepaRG cells. Ten EDCs-bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS), cadmium chloride (CdCl

Indexed as

Carbohydrate MetabolismEndocrine DisruptorsHepatocytesLiverBisphenol F CompoundsBisphenol S CompoundsCell LineConstitutive Androstane ReceptorGlucoseGlycogenHumansPhenolsPregnane X ReceptorReceptors, Cytoplasmic and NuclearReceptors, SteroidBisphenol F CompoundsBisphenol S CompoundsConstitutive Androstane ReceptorEndocrine DisruptorsGlucoseGlycogenPhenolsPregnane X ReceptorReceptors, Cytoplasmic and NuclearReceptors, SteroidChemicalsEndocrine disruptorsGlucoseHepaRGMechanistic toxicology

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.