ArticleArchives of toxicology2026
Applicability of in vitro mouse lung epithelial cell responses for potency grouping and hazard identification of metal oxide nanoparticles: impact of form, size, surface area, and solubility on toxicity.
Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- New approach methodologies for next-generation risk assessment of nanomaterials and nano-enabled products.Nano convergence · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human health risk assessment of engineered nanomaterials (ENM; materials with any dimension or structure between 1 and 100 nm) is challenged by the large number of compounds requiring assessment and the intricate association between physicochemical properties and toxicity. Previously, a number of high-content and high-throughput Novel Approach Methodologies (NAMs) were applied to investigate the impact of dissolution on toxicity induced by metal oxide (MOs) nanoparticles (NPs) in lung epithelial cells. This study evaluated the applicability of the data, including information from cell viability, transcriptomics, and genotoxicity endpoints, to conduct potency grouping and hazard identification for 7 individual MOs and their forms-NPs, dissolved equivalents, and bulk microparticle (MPs) analogues (18 total compounds). Benchmark concentration modeling was performed across a range of benchmark responses (BMRs), followed by hierarchical clustering to facilitate potency grouping and hazard identification. Correlation was assessed between endpoints used for potency grouping, and between endpoints and primary particle size, specific surface area, and solubility in cell culture medium across all BMRs. Instantaneously dissolving zinc oxide (ZnO) NPs presented similar potency to dissolved zinc and ZnO MPs, while aluminum oxide, iron oxide, and titanium dioxide NPs showed low potency. Thus, these particles were considered low priority for further testing. Copper oxide, nickel oxide and manganese dioxide NPs exhibited distinct potency and hazards compared to their dissolved or MPs forms, implying these particles warrant further assessment. Material solubility and the form of MOs were associated with endpoint potency. These results demonstrate the applicability of in vitro NAMs-based potency screening for first-tier assessment of MONP-induced acute toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.