ArticleWorld journal of microbiology & biotechnology2026
Evaluation of the efficacy of inactivated fecal transplants against Clostridioides difficile: an in vitro study.
Article in World journal of microbiology & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Predictors of RecurrentDiagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fecal microbiota transplantation (FMT) requires rigorous donor screening, limiting donor eligibility and increasing costs. Recent evidence suggests that bacterial viability may not be essential for treating recurrent Clostridioides difficile infections. This study aimed to evaluate whether inactivated fecal preparations retain anti-C. difficile (CD) activity in vitro. Stool samples from three donors underwent eight different inactivation protocols, including mechanical, thermal, and chemical treatments. Bacterial viability and anti-CD activity were assessed by culture and inhibition assays. Mechanical filtration, pasteurisation, and sterilisation eliminated bacterial growth, while tyndallisation and ethanol treatments only partially reduced viability. Inhibition of CD growth was observed exclusively in samples containing live bacteria, with no significant difference compared to native stool. Inactivated samples, despite potentially retaining other microbiota-derived components, showed no anti-CD activity. These results suggest that live bacteria are essential for in vitro antagonism of C. difficile and thus in the therapeutic effects of FMT.
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