Trial reportArchives of women's mental health2026
A randomized controlled trial of an electronic patient decision aid (PDA) for decision-making around antidepressant use in pregnancy.
Trial report in Archives of women's mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- When caution becomes harm.Nature medicine · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDecisions about whether to use antidepressant medication in pregnancy can be complex for patients. When decisional conflict is high, this can negatively impact on decision-making and resultant clinical outcomes. We evaluated an electronic patient decision aid (PDA) around antidepressant use in pregnancy for its ability to improve patients’ decision-making experience and the clinical outcomes associated with their decisions.
methodsThis parallel-group trial (2018–2025) randomized preconception and pregnant Canadian participants with depression in a 1:1 ratio to an electronic PDA plus standard resources or standard resource control. Groups were compared on decisional conflict (measured using the Decisional Conflict Scale, DCS) at 4 weeks post-randomization. Those who were pregnant/became pregnant were evaluated for postpartum depression (PPD) at 3 months postpartum using the Structured Clinical Interview for DSM-5.
resultsOf n = 462 participants, n = 231 (mean age 32.4 +/- 4.0 years. 48.3% pregnant at baseline) were randomized to the PDA and n = 231 (mean age 32.5 +/- 4.2 years. 48.1% pregnant at baseline) to control. Between baseline and 4-weeks post-randomization, mean (SD) DCS score decreased from 48.3 (13.1) to 33.9 (14.9) in the PDA condition and 47.9 (14.5) to 40.1 (17.0) in controls, an adjusted mean difference of -6.34 (95%CI -8.92 to -3.79). PPD at 3 months postpartum was present in 7 (6.0%) PDA and 15 (12.9%) control participants, an absolute risk difference of -6.9% (95% CI -14.4% to 0.5%).
conclusionsCompared to standard resources alone, our PDA plus standard resources significantly reduced decisional conflict about the decision of whether or not to use antidepressant medication in pregnancy. PPD rates at 3 months postpartum were non-significantly lower in the PDA group as well. These results support dissemination of the PDA, and the evaluation of its utility with a wider audience.
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