Evidence map›Paper›PMID 41606348›Full record

ArticleJournal of natural medicines2026

Polyphenols from the aerial parts of Lespedeza cuneata and their inhibitory effects on PTP1B and α-glucosidase: insights from in vitro and in Silico analyses.

Thi Nguyet Anh Dinh, Thi Ly Pham, Viet Phong Nguyen, Taeho Lee, Byung Sun Min, Jeong Ah Kim

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Process Optimization and Flavor Analysis ofFoods (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thi Nguyet Anh DinhVessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41,566, Republic of Korea.
Thi Ly PhamVessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41,566, Republic of Korea.
Viet Phong NguyenVessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41,566, Republic of Korea.
Taeho LeeBK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41,566, Republic of Korea.
Byung Sun MinCollege of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk, 38,430, Republic of Korea. bsmin@cu.ac.kr.
Jeong Ah KimVessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, 41,566, Republic of Korea. jkim6923@knu.ac.kr.ORCID http://orcid.org/0000-0001-7337-1812

Funding

National Research Foundation of Korea (NRF) NRF-2020R1A5A2017323
6 · The paper itself

Abstract

A comprehensive phytochemical investigation of the methanol extract from the aerial parts of Lespedeza cuneata resulted in the isolation of 36 compounds, including three new C-glycosyl flavonoids (8, 9, and 11). Their structures were elucidated using HRFAB-MS, as well as 1D and 2D nuclear magnetic resonance spectroscopy, and the isolated compounds were evaluated for inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase. Flavonoids 1, 17, and 21 exhibited potent PTP1B inhibition (IC

Indexed as

alpha-GlucosidasesGlycoside Hydrolase InhibitorsLespedezaPlant ExtractsPolyphenolsProtein Tyrosine Phosphatase, Non-Receptor Type 1Molecular Docking SimulationMolecular Dynamics SimulationPlant Components, Aerialalpha-GlucosidasesGlycoside Hydrolase InhibitorsPlant ExtractsPolyphenolsProtein Tyrosine Phosphatase, Non-Receptor Type 1Lespedeza cuneataMolecular dockingMolecular dynamicsPTP1Bα-glucosidase

Identifiers

PMID41606348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.