Evidence map›Paper›PMID 41606331›Full record

ArticleNature2026

GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling.

Peiyuan Chai, Sina Kheiri, Andrew Kuo, Jessica Shah, Lauren Kageler, Ruiqi Ge, Jonathan Perr, Jennifer Porat, Charlotta G Lebedenko, Joao M L Dias and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. The cellular landscape of druggable RNA-binding proteins.Nature reviews. Drug discovery · 2026
    Review
  2. Review
  3. 4D force patterning enables spatial control of angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Defining cell surface and glycosylated RNAs.Trends in genetics : TIG · 2026
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Peiyuan ChaiStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Sina KheiriDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-9934-4297
Andrew KuoVascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.
Jessica ShahDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-0760-4232
Lauren KagelerStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Ruiqi GeStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Jonathan PerrStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0014-2565
Jennifer PoratStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-1709-4635
Charlotta G LebedenkoStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Joao M L DiasWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Eliza YankovaWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2913-0012
Sandeep K RaiStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Christopher P WatkinsStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Petar HristovStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA.
Konstantinos TzelepisWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4865-7648
Timothy HlaVascular Biology Program, Boston Children's Hospital, Department of Surgery, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8355-4065
Ritu RamanDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Eliezer CaloDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-3006-2742
Jeffrey D EskoDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-8322-1834
Ryan A FlynnStem Cell and Regenerative Biology Program, Division of Hematology/Oncology, Department of Pediatrics, Boston Children's Hospital, Boston, MA, USA. ryan.flynn@childrens.harvard.edu.ORCID 0000-0001-5013-0442

Funding

Protein Glycosylation in the Coagulopathy and Inflammation of SepsisP01HL131474 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MAHAN, MICHAEL J · 2016 to 2025
$26.2M
Functional characterization of cell surface RNA biologyR01ES037423 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI Ryan Alexander Flynn · 2024 to 2026
$4.2M
Mechanisms and functions of cell surface glycoRNAsR35GM151157 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI Ryan Alexander Flynn · 2023 to 2026
$1.8M
NHLBI NIH HHS P01 HL131474NIEHS NIH HHS R01 ES037423NIGMS NIH HHS R35 GM151157
6 · The paper itself

Abstract

Heparan sulfate proteoglycans (HSPGs) have been recognized as key plasma membrane-tethered co-receptors for a broad range of growth factors and cytokines containing cationic heparan-binding domains

Indexed as

Heparan SulfateSignal TransductionVascular Endothelial Growth Factor AAnimalsEndothelial CellsHeparan Sulfate ProteoglycansHumansHuman Umbilical Vein Endothelial CellsMiceProtein BindingHeparan SulfateHeparan Sulfate ProteoglycansVascular Endothelial Growth Factor A

Identifiers

PMID41606331
PMCPMC12999495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.